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Distributes to a limited extent into CSF

Food and Drug Administration. WebMD does not endorse any specific product, service or treatment. This list is not complete and there are many other drugs that can interact with nitroglycerin. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Mohamed AA, Mendelow AD, Teasdale GM et al. Effect of the calcium antagonist nimodipine on local cerebral blood flow and metabolic coupling. J Cereb Blood Flow Metab. It is very important that your doctor check your progress at regular visits to make sure nimodipine is working properly and to check for unwanted effects. generic nimodipine order shop

Refer to adult dosing

What other drugs will affect nitroglycerin Nitrostat? Allen GS. Nimodipine for cerebral arterial spasm in subarachnoid hemorrhage. N Engl J Med. For enteral administration ONLY. Life-threatening adverse events have occurred when administered parenterally. Administer on an empty stomach at least 1 hour before or 2 hours after meals. HYDROcodone: CYP3A4 Inhibitors Weak may increase the serum concentration of HYDROcodone. Elderly: Initiate at a lower dose in the elderly.

Important information

Kazda S, Towart R. Nimodipine, a new calcium antagonistic drug with a preferential cerebrovascular action. Acta Neurochirurgica. Phenobarbital can speed up the removal of many other medications from your body, which may affect how they work. Roine RO, Kaste M, Kinnunen A et al. Safety and efficacy of nimodipine in resuscitation of patients outside hospital. BMJ. You may feel a slight burning or stinging in your mouth when you use this medication. However, this sensation is not a sign of how well the medication is working. Do not use more medication just because you do not feel a burning or stinging.

It may harm an unborn baby

Rarely, abnormal drug-seeking behavior is possible with this medication. not increase your dose, take it more frequently, or use it for a longer time than prescribed. Properly stop the medication when so directed. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Cardiovascular effects have frequently been associated with the use of nimodipine, and are related to its vasodilatory properties. Mild to moderate hypotension has been reported in up to 5% of patients, and was the reason less than 1% of patients chose to discontinue therapy. Bradycardia has been reported and may be severe in rare cases. Rare cardiovascular side effects have included tachycardia, hypertension, peripheral edema, dizziness, and flushing. A case of pulmonary vasoconstriction has been associated with the use of this drug.



Nimodipine forms and strengths

Amphetamines: May diminish the antihypertensive effect of Antihypertensive Agents. Tell your doctor if your condition does not get better or if it gets worse. Table 1 by dose. US labeling for similar amlodipine-containing combination products states that there is no evidence of a significant interaction. IV: The manufacturer recommends titrating slowly in patients with liver dysfunction or reduced hepatic blood flow. Lower dosages should be considered and response should be monitored closely in such patients. Mathew NT, Rivera VM, Meyer JS et al. Double-blind evaluation of glycerol therapy in acute cerebral infarction. Lancet. If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Do not administer contents of nimodipine oral capsules by IV or other parenteral routes. Nisoldipine is highly metabolized; 5 major urinary metabolites have been identified. Although 60 - 80% of an oral dose undergoes urinary excretion, only traces of unchanged Nisoldipine are found in urine. The major biotransformation pathway appears to be the hydroxylation of the isobutyl ester. A hydroxylated derivative of the side chain, present in plasma at concentrations approximately equal to the parent compound, appears to be the only active metabolite, and has about 10% of the activity of the parent compound. Cytochrome P450 enzymes are believed to play a major role in the metabolism of Nisoldipine. The particular isoenzyme system responsible for its metabolism has not been identified, but other dihydropyridines are metabolized by cytochrome P450 IIIA4. Nisoldipine should not be administered with grapefruit juice, as this has been shown, in a study of 12 subjects, to interfere with Nisoldipine metabolism, resulting in a mean increase in C max of about 3-fold ranging up to about 7-fold and AUC of almost 2-fold ranging up to about 5-fold. A similar phenomenon has been seen with several other dihydropyridine calcium channel blockers. Refer to adult dosing. Kistler JP, Ropper AH, Martin JB. Cerebrovascular diseases. In: Braunwald E et al, eds. Espinosa F, Weir B, Overton T et al. A randomized placebo-controlled double-blind trial of nimodipine after SAH in monkeys. J Neurosurg. Nisoldipine has no clinically important chronotropic effects. Except for mild shortening of sinus cycle, SA conduction time and AH intervals, single oral doses up to 20 mg of immediate release Nisoldipine did not significantly change other conduction parameters. Similar electrophysiologic effects were seen with single IV doses, which could be blunted in patients pre-treated with beta-blockers. Dose and plasma level related flattening or inversion of T-waves have been observed in a few small studies. Such reports were concentrated in patients receiving rapidly increased high doses in one study; the phenomenon has not been a cause of safety concern in large clinical trials. Take nimodipine exactly as directed even if you feel well and do not notice any symptoms. Do not take more of nimodipine and do not take it more often than your doctor ordered. Do not miss any doses.



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Ask your doctor how long you should wait between your doses of these drugs. Blood pressure response increases over the 10 to 60 mg daily dose range but adverse event rates also increase. Doses beyond 60 mg once daily are not recommended. Nisoldipine, the active enantiomer, is about 6 times higher than the inactive - -Nisoldipine enantiomer. Talk to your doctor or about lifestyle changes that might benefit you. The manufacturer recommends caution during titration of this drug in patients with renal dysfunction. IV nicardipine should be titrated slowly in such patients. Consult your doctor before -feeding. Pharmacotherapy: a pathophysiologic approach. Reduce dosage to 30 mg every 4 hours in patients with cirrhosis. Koos WT, Perneczky A, Auer LM et al. Nimodipine treatment of ischemic neurological deficits due to cerebral vasospasm after subarachnoid hemorrhage: clinical results of a multicenter study. Neurochirurgia. Limited evidence suggests that nimodipine may improve neurologic recovery and reduce mortality compared with plasma volume expansion therapy or placebo in some patients with acute ischemic stroke. diltiazem



Hunt and Hess Grades I-V

If you have any questions about nimodipine oral solution, please talk with your doctor, pharmacist, or other health care provider. Fosphenytoin: Calcium Channel Blockers may increase the serum concentration of Fosphenytoin. Management: Monitor for phenytoin toxicity with concomitant use of a calcium channel blocker CCB or decreased phenytoin effects with CCB discontinuation. Monitor for decreased CCB therapeutic effects. Nimodipine Canadian labeling contraindicates use with phenytoin. What should I discuss with my healthcare provider before taking nitroglycerin Nitrostat? Do not eat grapefruit or drink grapefruit juice while you are using nimodipine. Laursen J, Jensen F, Mikkelsen E et al. Nimodipine treatment of subarachnoid hemorrhage. Clin Neurol Neurosurg. Huyghens LP, Buylaert WA, Corne L et al. Plasma concentrations and haemodynamic effects of nimodipine in patients resuscitated after cardiac arrest. Eur J Clin Pharmacol. Nisoldipine was demonstrated by 24 hour blood pressure monitoring and examination of peak and trough effects. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication not have serious side effects. Do not stop taking any medications without consulting your healthcare provider. Nisoldipine tablets in epileptic patients lowered the Nisoldipine plasma concentrations to undetectable levels. Far more commonly, though, repeated and distinct episodes of dominate the picture. Repeated periods of are punctuated by infrequent, shorter periods of elevated or normal mood. How Is Rapid Cycling Bipolar Disorder Identified? Each package contains one 20 mL Unit-Dose cup NDC 24338-200-20 and one oral syringe. The dosage of PROCARDIA needed to suppress angina and that can be tolerated by the patient must be established by titration. Excessive doses can result in hypotension. Nimodipine oral solution is to be used only by the patient for whom it is prescribed. Do not share it with other people. order allopurinol payment usa allopurinol



St John's wort, among others

Do not suddenly stop taking this medication without consulting your doctor. This medication is usually taken for 2 to 4 weeks. Follow your doctor's directions carefully. Your condition may become worse if the drug is stopped too soon. Ceritinib: May increase the serum concentration of CYP3A4 Substrates. If your symptoms do not improve or if they become worse, check with your doctor. The contents of the capsule should not be admixed with any solution prior to oral administration because of the possibility of drug decomposition. CYP3A4 Inhibitors Strong: May increase the serum concentration of NiMODipine. This drug has rarely caused very serious , . Your doctor will monitor your blood counts to minimize the chance of these side effects. Keep all medical and lab appointments. Bongianni F, Carla V, Moroni F. Calcium channel inhibitors suppress the morphine-withdrawal syndrome in rats. Br J Pharmacol. Fosaprepitant: May increase the serum concentration of CYP3A4 Substrates. Kirsch JR, Dean JM, Rogers MC. Current concepts in brain resuscitation. Arch Intern Med. For example, in one study of people with bipolar II disorder, the amount of time spent depressed was more than 35 times the amount of time spent hypomanic. Also, people often don't take note of their own hypomanic symptoms, mistaking them for a period of unusually good mood. How Is Bipolar Disorder with Rapid Cycling Treated? Pharmacol Exp Ther. 1983; 225: 291-309. mail order cheapest butenafine europe



What should i avoid while taking nimodipine

Gelmers HJ. Effect of calcium antagonists on the cerebral circulation. Am J Cardiol. 1987; 59: 173-6B. If you are taking the extended-release tablets, take them usually every 12 hours or as directed by your doctor. Do not crush or chew extended-release tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split the tablets unless they have a score line and your doctor or tells you to do so. Swallow the whole or split tablet without crushing or chewing. It has been suggested that the drug may be discontinued after 14 consecutive days but not earlier in some uncomplicated cases in which early aneurysm surgery is performed. Cimetidine: May increase the serum concentration of Calcium Channel Blockers. Management: Consider alternatives to cimetidine. Sobota JT. Review of cardiovascular findings in humans treated with minoxidil. Toxicol Pathol. Neuromuscular-Blocking Agents Nondepolarizing: Calcium Channel Blockers may enhance the neuromuscular-blocking effect of Neuromuscular-Blocking Agents Nondepolarizing. Heikkinen ER, Koivukangas J. Surgery of vertebrobasilar aneurysms and nimodipine. Ann Clin Res. Seek emergency medical attention if your chest pain gets worse or lasts more than 5 minutes, especially if you have trouble breathing or feel weak, dizzy, or nauseated, or lightheaded. Honn KV, Onoda JM, Diglio CA et al. Inhibition of tumor cell-platelet interactions and tumor metastasis by the calcium channel blocker, nimodipine. Clin Exp Metastasis. Factors identified by FDA as contributing to this error include use of IV syringes to administer the drug by NG tube IV syringes sometimes are used to remove the liquid contents from the capsules and the fact that most patients receiving the drug are in critical care settings and are receiving other IV therapy.



Table 1 by dose

Nisoldipine is a yellow crystalline substance, practically insoluble in water but soluble in ethanol. It has a molecular weight of 388. Nisoldipine to these events cannot be established, they are listed to alert the physician to a possible relationship with Nisoldipine treatment. Benperidol: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Steen PA, Newberg LA, Milde JH et al. Cerebral blood flow and neurologic outcome when nimodipine is given after complete cerebral ischemia in the dog. J Cereb Blood Flow Metab. In patients with chronic kidney disease CKD regardless of race or diabetes status, the use of an ACE inhibitor ACEI or angiotensin receptor blocker ARB as initial therapy is recommended to improve kidney outcomes. In the general nonblack population without CKD including those with diabetes, initial antihypertensive treatment should consist of a thiazide-type diuretic, calcium channel blocker, ACEI, or ARB. In the general black population without CKD including those with diabetes, initial antihypertensive treatment should consist of a thiazide-type diuretic or a calcium channel blocker instead of an ACEI or ARB. Chronic stable angina: Treatment of symptomatic chronic stable angina. May be used alone or in combination with other antianginal agents. F. Protect capsules from light and freezing. Protect solution from light and do not refrigerate. Grobe-Einsler R "Clinical aspects of nimodipine. discount vantin together



North American clinical trials

Overdose symptoms may include a severe throbbing headache, confusion, fever, fast or pounding heartbeats, dizziness, vision problems, nausea, vomiting, bloody diarrhea, trouble breathing, cold or clammy skin, feeling light-headed, fainting, and seizures. INTRAVENOUSLY OR BY OTHER PARENTERAL ROUTES. The effect of Nisoldipine on blood pressure is principally a consequence of a dose-related decrease of peripheral vascular resistance. While Nisoldipine, like other dihydropyridines, exhibits a mild diuretic effect, most of the antihypertensive activity is attributed to its effect on peripheral vascular resistance. Inform your doctor if your condition persists or worsens. Anon. Nimodipine for cerebral vasospasm after subarachnoid hemorrhage. Med Lett Drugs Ther. MI in patients with obstructive coronary disease, especially in the absence of concurrent beta-blockade. Calcium Salts: May diminish the therapeutic effect of Calcium Channel Blockers. Belfort MA, Saade GR, Moise KJ, Cruz A, Adam K, Kramer W, Kirshon B "Nimodipine in the management of preeclampsia: maternal and fetal effects. Hemodialysis or peritoneal dialysis not likely to affect elimination. Nimodipine is over 95% bound to plasma proteins. In another small study, four unselected pregnant women with hypertension, proteinuria, and seizures were given intravenous nimodipine during right heart catheterization with pulmonary artery pressure measurements. Significant reductions in systemic vascular resistance and mean arterial pressure were well-documented. There were no adverse effects on the mothers or fetuses and no significant changes in oxygen delivery or peripheral oxygen consumption during the study. Das G. Fundamentals of calcium channel blockers. Int J Clin Pharmacol Ther Toxicol. cheap podofilox ecuador podofilox



Prescribing information for nimodipine

Taylor JW, Cleary JD. Primary headache disorders. Kazda S. Pharmacology of nimodipine, a calcium antagonist with preferential cerebrovascular activity. Neurochirurgia. Idelalisib: May increase the serum concentration of CYP3A4 Substrates. Initiate therapy as soon as possible after the occurrence of subarachnoid hemorrhage, preferably within 96 hours. Toomey syringe. 246 250 To help minimize administration errors, label the syringe for oral use only; not for IV use. Widely distributed into body tissues after oral or IV administration in animals. Woie L, Storstein L. Successful treatment of suicidal verapamil poisoning with calcium gluconate. Nisoldipine does not appear to have significant negative inotropic activity in intact animals or humans, and did not lead to worsening of clinical heart failure in three small studies of patients with asymptomatic and symptomatic left ventricular dysfunction. There is little information, however, in patients with severe congestive heart failure, and all calcium channel blockers should be used with caution in any patient with heart failure. repaglinide



Nimodipine dosing information

II. Diazepam. Life Sci. Simeprevir: May increase the serum concentration of CYP3A4 Substrates. Tocilizumab: May decrease the serum concentration of CYP3A4 Substrates. Yellow No. 5 tartrazine sensitivity in the general population is low, it is frequently seen in patients who also have aspirin hypersensitivity. Kazner E, Sprung C, Adelt D et al. Clinical experience with nimodipine in the prophylaxis of neurological deficits after subarachnoid hemorrhage. Neurochirurgia. Mabe H, Nagai H, Takagi T et al. Effect of nimodipine on cerebral functional and metabolic recovery following ischemia in the rat brain. Stroke. It is best to take nimodipine at least 1 hour before or 2 hours after a meal. Nisoldipine were dose related over the clinical dosage range. CYP3A4 Inhibitors Weak: May increase the serum concentration of NiMODipine. It is not known whether Nisoldipine is excreted in human milk. Because many drugs are excreted in human milk, a decision should be made to discontinue nursing, or to discontinue Nisoldipine, taking into account the importance of the drug to the mother.



What is nimodipine

Tettenborn D, Porto L, Ryman T et al. Survey of clinical experience with nimodipine in patients with subarachnoid hemorrhage. Neurosurg Rev. 1987; 10: 77-84. Itil TM, Itil KZ. The comparative CNS pharmacology of nimodipine in humans. In: Betz E, Deck K, Hoffmeister F, eds. Nimodipine: pharmacological and clinical properties. Alfuzosin: May enhance the hypotensive effect of Blood Pressure Lowering Agents. It may harm an unborn baby. However, since untreated or are serious conditions that can harm both a woman and her unborn baby, do not stop taking this medication unless directed by your doctor. If you are planning pregnancy, become pregnant, or think you may be pregnant, discuss with your doctor right away the benefits and risks of using this medication during pregnancy. If you are pregnant, prenatal care that includes tests for is recommended. WebMD User Reviews should not be considered as medical advice and are not a substitute for professional medical advice, diagnosis, or treatment. Never delay or disregard seeking professional medical advice from your physician or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences may be a helpful health information resource but they are never a substitute for professional medical advice from a qualified healthcare provider. Have patient report immediately to prescriber bradycardia, abnormal heartbeat, shortness of breath, excessive weight gain, swelling of arms or legs, severe dizziness, or passing out HCAHPS. Blood pressure should be monitored closely during any dosage adjustment. Symptomatic hypotension with or without syncope can occur; blood pressure must be lowered at a rate appropriate for the patient's clinical condition. Monitor blood pressure closely during treatment. glyburide purchase now europe



Use of nimodipine

PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using nimodipine oral solution while you are pregnant. It is unknown if nimodipine oral solution is excreted in breast milk. Do not breast-feed while you are using nimodipine oral solution. Dapoxetine: May enhance the orthostatic hypotensive effect of Calcium Channel Blockers. May distribute more extensively into CSF in patients with subarachnoid hemorrhage. Siltuximab: May decrease the serum concentration of CYP3A4 Substrates. Store at room temperature away from light and moisture. Avoid freezing the liquid. not store in the bathroom. Keep all away from children and pets. Diarrhea; dizziness; headache; nausea. The nitroglycerin sublingual tablet should be placed under your tongue and allowed to dissolve slowly. Do not chew or swallow it. You may use additional tablets every 5 minutes, but not more than 3 tablets in 15 minutes. Eur J Drug Metab Pharmacokinet. Do not use nitroglycerin if you are taking sildenafil Viagra, Revatio tadalafil Cialis or vardenafil Levitra. Serious, life-threatening side effects can occur if you take nitroglycerin while you are using sildenafil. Usual maintenance dosage is 17 to 34 mg once daily. Auer LM. Preventive nimodipine and acute aneurysm surgery: heading for the control of complications after aneurysmal subarachnoid hemorrhage. Neurochirurgia. Because dominate in most people with a rapid cycling course of bipolar disorder, treatment is usually aimed toward stabilizing mood, mainly by relieving depression while preventing the comings-and-goings of new episodes. Patient may experience fatigue, loss of strength and energy, flushing, nausea, or abdominal pain. Have patient report immediately to prescriber signs of liver problems dark urine, fatigue, lack of appetite, nausea, abdominal pain, light-colored stools, vomiting, or jaundice severe dizziness, passing out, angina, tachycardia, abnormal heartbeat, shortness of breath, excessive weight gain, muscle rigidity, tremors, abnormal movements, or swelling of arms or legs HCAHPS. Dofetilide: CYP3A4 Inhibitors Weak may increase the serum concentration of Dofetilide. Bipolar disorder is diagnosed after someone experiences a hypomanic or manic episode along with multiple additional episodes of either mania, hypomania or depression. Rapid cycling in itself is not a diagnosis, but rather a "course specifier" or descriptor of the course of illness. In bipolar disorder rapid cycling is identified when four or more distinct episodes of depression, mania, or hypomania occur during a one year period. Rapid cycling can occur at any time in the course of bipolar disorder and may come and go at varying points over a lifetime. The authors concluded that nimodipine is transferred to human milk in a lower proportion than other calcium channel blockers, and that the risk for the nursing infant is theoretically negligible at the maternal doses given. lzip.info femara



About nimodipine

Children may be more sensitive to the side effects of this drug. This drug can often cause excitement instead of drowsiness in young children. Auer LM, Oberbauer RW, Schalk HV. Human pial vascular reactions to intravenous nimodipine-infusion during EC-IC bypass surgery. Stroke. CYP3A4 Inducers Moderate: May decrease the serum concentration of NiMODipine. The IV infusion should be discontinued if hypotension or tachycardia occurs. Inactive ingredients in the formulation include: Hypromellose, hypromellose phthalate, lactose, glyceryl behenate, povidone, magnesium stearate, silicon dioxide, methacrylic acid copolymer, and sodium lauryl sulfate. Inactive ingredients in the film coating include: polydextrose, titanium dioxide, hypromellose, polyethylene glycol, iron oxide, and carnauba wax. Ask your health care provider any questions you may have about how to use nimodipine oral solution. Hypertension: Treatment of hypertension. florinef



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Nimodipine warnings


Nimodipine overdose

Jan M, Buchheit F, Tremoulet M "Therapeutic trial of intravenous nimodipine in patients with established cerebral vasospasm after rupture of intracranial aneurysms. Herbs Hypotensive Properties: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Mohamed AA, McCulloch J, Mendelow AD et al. Effect of the calcium antagonist nimodipine on local cerebral blood flow: relationship to arterial blood pressure. J Cereb Blood Flow Metab. The of nimodipine is mediated by CYP3A4. HGRPT assay for mutagenicity and the in vivo mouse micronucleus test and in vitro CHO cell test for clastogenicity. purchase now xtane online usa

What happens if I miss a dose Nitrostat?

Gilsbach JM, Harders AG, Eggert HR et al. Early aneurysm surgery: a 7 year clinical practice report. Acta Neurochir Wien. Since nitroglycerin is taken as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if your next dose is less than 2 hours away. Do not take extra medicine to make up the missed dose. Nimodipine is used to decrease problems due to a certain type of bleeding in the brain subarachnoid hemorrhage-SAH. Manufactured for: Atlanta, GA 30328. Pellettieri L, Bolander H, C et al. Nimodipine treatment of selected good-risk patients with subarachnoid hemorrhage: no significant difference between present and historical results. Surg Neurol.

List of nimodipine side effects

Ramadan NM, Silberstein SD, Freitag FG et al. Evidence-based guidelines for migraine headache in the primary care setting: pharmacological management for prevention of migraine. St. Paul, MN; 2001. From the American Academy of Neurology web site. Subarachnoid hemorrhage: Oral: 60 mg every 4 hours for 21 consecutive days. Note: Start therapy within 96 hours of the onset of subarachnoid hemorrhage. Do not chew the mixture or prepare a supply in advance. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Side effects of nimodipine

Vinge E, Brandt L, Ljunggren B et al. Thromboxane B 2 levels in serum during continuous administration of nimodipine to patients with aneurysmal subarachnoid hemorrhage. Stroke. If the test shows you are at greater risk, your doctor should discuss the risks and benefits of carbamazepine and other treatment choices with you. Such skin reactions have developed mostly within the first few months of treatment. Auer LM, Ito Z, Suzuki A et al. Prevention of symptomatic vasospasm by topically applied nimodipine. Acta Neurochir.

Torrealba G, Sharp A, Soto B. Nimodipine-treated subarachnoid hemorrhage associated with acute pseudo-obstruction of the colon. Surg Neurol. Nisoldipine is a member of the dihydropyridine class of calcium channel antagonists calcium ion antagonists or slow channel blockers that inhibit the transmembrane influx of calcium into vascular smooth muscle and cardiac muscle. It reversibly competes with other dihydropyridines for binding to the calcium channel. Because the contractile process of vascular smooth muscle is dependent upon the movement of extracellular calcium into the muscle through specific ion channels, inhibition of the calcium channel results in dilation of the arterioles. In vitro studies show that the effects of Nisoldipine on contractile processes are selective, with greater potency on vascular smooth muscle than on cardiac muscle. Although, like other dihydropyridine calcium channel blockers, Nisoldipine has negative inotropic effects in vitro, studies conducted in intact anesthetized animals have shown that the vasodilating effect occurs at doses lower than those that affect cardiac contractility.

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